Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

MAN2B2

contributors: mct - updated : 24-01-2014

HGNC name	mannosidase, alpha, class 2B, member 2
HGNC id	29623

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_015274 19 - 4242 NP_056089 - 1009 - 2009 19722277

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Digestive liver       highly Nervous brain       highly Reproductive female system ovary     highly Respiratory lung       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Nervous central

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a glycosyl hydrolases family 38 N-terminal domain
	a glycosyl hydrolases family 38 C-terminal domain

conjugated

GlycoP

isoforms

Precursor

a peptide signal from the 1st to 23th aa

HOMOLOGY

intraspecies

homolog to alpha-D mannosidase

Homologene

FAMILY

glycosylhydrolase 38 family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	extracellular
	intracellular,cytoplasm,organelle,lysosome
text	secreted

basic FUNCTION	hydrolase activity on terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides
	may be fonctionning in tandem with chitobiase (CTBS) in N-glycan catabolism
	MAN2B1, MAN2B2 act in a complementary fashion on different glycosidic linkages, to effect glycan degradation in the lysosome

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

carbohydrate

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS