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FLASH GENE
Symbol STX8 contributors: mct/npt/pgu - updated : 04-06-2013
HGNC name syntaxin 8
HGNC id 11443
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 988 27 236 - 1999 10198254
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen    
Cardiovascularheart    
Digestiveliver    
Endocrinepancreas    
Respiratorylung    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
Muscularstriatumcardiac  
Muscularstriatumskeletal  
Nervouscentral   
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
cell cycle     cell cycle, interphase, G2
Text placenta
PROTEIN
PHYSICAL PROPERTIES Hydrophobic
STRUCTURE
motifs/domains
  • a C terminal hydrophobic
  • a coild-coil domains
  • a helical domain involved in the formation of a SNARE complex
  • in the cytoplasmic domain, two functionally distinct di-leucine-based motifs that act independently in its endocytic and exocytic processes
  • mono polymer heteromer , trimer
    HOMOLOGY
    interspecies homolog to murine Stx8
    homolog to C.elegans r12c12.5
    Homologene
    FAMILY
  • syntaxin epimorphin family
  • SNARE family of protein
  • CATEGORY regulatory , transport
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    text
  • preferentially associated with early endosome,predominantly with the centrosome and mitotic spindle poles
  • anchored to membrane by a C terminal hydrophobic domains
  • basic FUNCTION
  • soluble N ethylmaleimide-sensitive factor-attachment protein receptor, SNARE protein
  • involved in the intracellular membrane transport and exocytosis
  • regulating secretory vesicle transport, docking and fusion
  • mediating retrograde transport from CIS-Golgi membranes to the ER
  • contributes to the regulation of CFTR trafficking and chloride channel activity by the SNARE machinery
  • SNARE protein required for late-endosome fusion, as a ERRFI1-binding protein to form a complex with EGFR during receptor trafficking
  • regulates the trafficking of EGFR from early to late endosomes
  • is a modulator of NTRK1 cell surface levels and biological functions
  • CELLULAR PROCESS cell cycle, division, mitosis
    PHYSIOLOGICAL PROCESS exocytosis transport
    text small molecule and vesicular transport
    PATHWAY
    metabolism
    signaling
    a component
  • regulatory subunit of a snare complex with syntaxin 7, VTI1B and endobrevin/VAMP8
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • coregulating CCNB1 with CDKN1A
  • physically interacts with CFTR (strong inhibition of CFTR chloride current by syntaxin 8 overexpression)
  • endosomal SNARE proteins physically and functionally interact with CFTR
  • directly interacts with HECTD3 and the overexpression of HECTD3 promotes the ubiquitination of STX8
  • strong interaction between ERRFI1 and STX8 upon ligand activation therefore ensures recruitment of internalized EGFR to late endosomes and subsequently the lysosomal degradation compartment
  • partners of CLN8 are VAPA, C14orf1/hERG28, STX8, GABARAPL2, BNIP3 and BNIP3L proteins and are associated with biologically relevant processes such as synthesis and transport of lipids, vesicular/membrane trafficking, autophagy/mitophagy and apoptosis
  • STX8 interacts with the acid-sensitive potassium channel KCNK3, and regulates the endocytosis of KCNK3
  • STX8 facilitates NTRK1 transport from the Golgi to the plasma membrane and regulates the surface levels of NTRK1 but not NTRK2 receptors
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS