basic FUNCTION
| half ABC transporter traffic ATPase, involved in transport of specific molecules into or out the placenta |
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xenobiotic transporter, multidrug resistance of breast cell(daunorubicin, rhodamine) |
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confers resistance to the anticancer drug mitoxantrone in breast cancer cell lines |
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playing a physiolo)gic roles in protection of primitive stem cell populations |
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functions as a dimer, but do not exclude functional higher order oligomers |
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involved in the efflux of various anticancer compounds such as mitoxantrone, doxorubicin and topoisomerase I inhibitor |
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might play a significant role in maintaining neural stem cells in an undifferentiated state and in protecting this stem cells from xenobiotics or other toxic substances |
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transporter restricting absorption and enhancing excretion of many compounds including anticancer drugs, and may be important in renal drug excretion |
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playing an important role in clinical drug resistance |
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may serve to mediate cholesterol removal |
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may play a hitherto unrecognized survival role in the placenta, protecting the trophoblast against cytokine-induced apoptosis and possibly other extrinsic activators via modulation of ceramide signaling |
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confers resistance to cancer cells by mediating the ATP-dependent outward efflux of chemotherapeutic compounds |
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urate efflux transporter, mediating renal urate secretion |
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having functional activity leading to drug efflux |
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role of ABCG2 in stem cell regulation and protection against hypoxia |
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exports heme, and binds porphyrins, preferably the metal-chelated forms, to its large extracellular domain ECL3 |
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may protect corneal epithelial progenitor SP cells against oxidative stress induced by toxins and hypoxia |
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potential important role in positively regulating skeletal muscle regeneration |