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FLASH GENE
Symbol GALNT3 contributors: mct - updated : 03/10/2008
HGNC name UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3)
HGNC id 4125
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 - 3280 72.6 633 - 2007 17351710
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus   highly
 intestinelarge intestinecolon highly
 mouth   highly
Reproductivefemale systemovary  highly Homo sapiens
 male systemtestis  highly Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductivegerm cell Homo sapiens
Reproductiveoocyte Homo sapiens
Reproductivespermatozoa Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • near the N terminus, a stem region, a lumenal catalytic domain
  • a GT1 motif and Ga1/Ga1 NAc transferase motif
  • a C terminal ricin/lectin-like domain, including a QXW lectin repeat
    • HOMOLOGY
    interspecies ortholog to bovine galnt3
    Homologene
    FAMILY
  • glycosyltransferase 2 family
  • GalNAc-T subfamily
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • catalyzing the initial reaction in O-linked (mucin type) oligosaccharide biosynthesis
  • possessing substrate specificity for fibronectin (fetal and plasma)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
  • Ca2+
  • Mn2+
    • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) FTC1
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in pancreas non differentiated
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS