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FLASH GENE

Symbol

MYOM1

contributors: mct - updated : 29-08-2011

HGNC name	myomesin 1, 185kDa
HGNC id	7613

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

text	with several isoforms two alternatively spliced forms myomesin and skelemin (in mouse) (Steiner)

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_003803 38 - 5848 isoform a 187.5 1685 - 1999 10036188 NM_019856 37 - 5560 isoform b 177.7 1589 - 1999 10036188

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic spleen       highly Cardiovascular heart       highly Digestive liver       moderately Endocrine pancreas       moderately Nervous brain       moderately Reproductive male system prostate     moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine   Muscular striatum skeletal     Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a unique N terminal region, N-terminal domain 1 of myomesin interacts with the alpha-helical tail domain of Myosin, while the myomesin domains 4–6 bind to the C-terminus of titin
	12 modules of motif I (fibronectin type III) or motif II -immunoglobulin C2) in the arrangement II-II-I-I-I-I-I-II-II-II-II-II
	C-terminal domain 13 of myomesin dimerises and forms antiparallel strands which cross-link neighboring Myosin filaments and titin in the M-line of the sarcomeres

HOMOLOGY

interspecies	homolog to murine Myom1
	homolog to C.elegans t24b8.7a

Homologene

FAMILY

Ig superfamily

CATEGORY

structural protein

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytoskeleton
text	sarcomeres, M bands and Z discs
	located in the M-band which is found in all types of vertebrates striated muscle

basic FUNCTION	playing a role in muscle contraction, cell shape and cell size control
	myomesin is an essential sarcomeric component controlling the assembly and maintenance of the A-band structure whereas the M-protein increases the stability of the thick filament lattice in some kind of muscles
	plays an important structural and functional role in the M-band of striated muscles

CELLULAR PROCESS	cell life, proliferation/growth
	cell organization/biogenesis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component	constituent of meromyosin (binding the globular head of titin and the central region of light meromyosin), potentially involved in the assembly and/or stabilization of myofibrils protein constituent of sarcomeric M-band
	myomesin dimers cross-link neighboring Myosin and titin filaments in the M-line of the sarcomeres stabilising the contractile apparatus during striated muscle contraction

INTERACTION

DNA

RNA

small molecule

protein	binding to myosin
	binding to titin
	binding to light meromyosin
	binding to integrin for transmission of signal leading to the initial steps of cell spreading

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

CMH14

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS