Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Orphanet	Ensembl
	HGNC	UniGene	Nucleotide	OMIM		UCSC

Home Page

FLASH GENE

Symbol

RAD51C

contributors: mct/pgu - updated : 10-07-2019

HGNC name	RAD51 homolog C (S. cerevisiae)
HGNC id	9820

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_058216 9 splicing 1295 NP_478123 - 376 - 2007 17114795 also called RAD51C-isoform 1 NM_002876 2 splicing 607 NP_002867 - 135 - 2007 17114795 also called RAD51C-isoform 2 variant 3 - splicing 1130 isoform 3 - 134 - 1998 9469824

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Digestive pharynx       highly Endocrine parathyroid       highly Reproductive female system breast mammary gland   highly   male system prostate       Skin/Tegument skin       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow     highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a nuclear localization signal (NLS)
	two ATP binding domains

HOMOLOGY

interspecies

homolog to yeast S.cerevisiae Rad51,3

intraspecies	paralog to RAD51
	paralog to XRCC3

Homologene

FAMILY	RECA family
	RAD51 subfamily

CATEGORY

DNA associated

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria
	intracellular,nucleus,nucleoplasm

basic FUNCTION	involved in mitosis and meiotic recombination events
	required for holliday junction processing in recombination process and for gene conversion
	important role in maintaining correct centrosome numbers and the complexes including RAD51C and XRCC2 or XRCC3 may be of importance in maintaining correct centrosome numbers in mitosis
	might be important in preventing aneuploidy, suggesting that it could be a potential tumour suppressor
	adequate expression of RAD51C in cells is essential for maintaining genomic stability and sister chromatid cohesion to prevent malignant transformation
	functions as TP53-dependent tumor suppressor gene
	first moderate-to-high risk susceptibility gene for ovarian cancer
	RAD51B, RAD51C, RAD51D, XRCC2 and XRCC3, play an essential role in the DNA repair reactions through homologous recombination
	rare breast and ovarian cancer susceptibility gene
	plays a vital role in the homologous recombination-mediated repair of DNA lesions associated with replication
	critical role of RAD51C in the Fanconi anemia pathway of interstrand cross-link repair and as a tumor suppressor
	RAD51B, RAD51C, RAD51D, XRCC2 and XRCC3 are key enzymes for DNA double-strand break repair
	RAD51B and RAD51C act early in homologous recombination
	likely a direct role of RAD51C/XRCC3 in maintaining mtDNA integrity under replication stress conditions
	RAD51B, RAD51C, RAD51D, XRCC2, XRCC3 sequentially orchestrate clinically relevant transactions at replication forks, cooperatively promoting fork remodeling and restart
	function of XRCC3 and other RAD51 paralogs in synergizing with RAD51 nucleoprotein filament to prevent degradation of stressed replication forks

CELLULAR PROCESS	cell cycle, division

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

pathway in cells for the repair of severe DNA damage such as double-strand breaks

a component	forms a complex that includes either XRCC2 or XRCC3
	member of the BCDX2 protein complex—comprising RAD51B, RAD51C, RAD51D, and XRCC2—which is thought to have several functions in HR, including stabilization of RAD51 nucleoprotein filaments
	RAD51C/XRCC3 is an additional component of the mitochondrial nucleoid having nucleus-independent roles in mtDNA maintenance

INTERACTION

DNA

RNA

small molecule

protein	RAD51B and XRCC3
	BRCA1 and BRCA2
	XRCC3 and RAD51C have been implicated in homologous recombination (HR) and DNA damage responses
	HELQ is associated with the RAD51 paralogs RAD51B/C/D and XRCC2, and with the DNA damage-responsive kinase ATR

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

FANCO

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over gain of function in breast cancer (in progression) constitutional     --low   results in a dramatic decrease in mtDNA copy number as well as the complete suppression of a characteristic oxidative stress-induced copy number increase tumoral germinal mutation     loss of function in patients with primary ovarian, fallopian tube, or peritoneal cancers tumoral germinal mutation       in breast and/or ovarian cancer families tumoral germinal mutation       germinal deleterious variants in the RAD51 paralogs to breast and ovarian cancers

Susceptibility

to breast and ovarian cancer

Variant & Polymorphism other	six monoallelic pathogenic mutations in RAD51C confer an increased risk for breast and ovarian cancer
	relative risk of ovarian cancer for RAD51C mutation carriers was augmented

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS