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FLASH GENE
Symbol GFRA2 contributors: mct/npt - updated : 07-07-2008
HGNC name GDNF family receptor alpha 2
HGNC id 4244
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 3376 51.5 464 - Vanhorne, Quartu(2007)
- - splicing 399 - - - Vanhorne
missing exons 2 and 3
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Nervousbrainmidbrainnuclei highly
Respiratorylung    
Visualeye    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone   
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal, pregnancy
Text placenta, brain, gut, intestine
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four cysteine residues linked by hinge regions
    • secondary structure nine alpha helices with two central beta strands
    conjugated GlycoP
    HOMOLOGY
    intraspecies homolog to GFRA1,GFRA3,GFRA4
    Homologene
    FAMILY
  • GDNFR family
    • CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    text anchored to the membrane by a C terminal glycosylphosphatidylinositol (GPI)-linkage
    basic FUNCTION
  • glycosylphosphatidylinositol linked cell surface coreceptor for GDNF, involved in RET signaling pathway
  • mediating the autophosphorylation of RET
  • also receptor for neurturin and TGF-beta-related neurotrophic factor
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS