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FLASH GENE
Symbol CYP11B1 contributors: mct/npt - updated : 02-06-2010
HGNC name cytochrome P450, family 11, subfamily B, polypeptide 1
HGNC id 2591
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 3551 57 503 - Barr (2007)
8 - 3353 49 437 - Barr (2007)
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineadrenal glandcortex   
Reproductivefemale systembreastmammary gland  
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal 24 AA mitochondrial signal sequence
  • conjugated HemoP
    mono polymer monomer
    isoforms Precursor
    HOMOLOGY
    interspecies homolog to bovine p-450 11 beta
    intraspecies homolog to CYP11B2
    Homologene
    FAMILY
  • cytochrome P450 subfamily XIB
  • multigenic cytochrome P450 superfamily of mixed-function monooxygenases
  • CATEGORY enzyme , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic,microsome
    basic FUNCTION
  • involved in glucocorticoid biosynthesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport
    PATHWAY
    metabolism hormone
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor, nucleotide,
  • NADPH, heme
  • protein
  • flavoprotein P450 oxidoreductase (POR)
  • cell & other
    REGULATION
    Other regulated by cyclic AMP (cAMP)-dependent signaling
    ASSOCIATED DISORDERS
    corresponding disease(s) CYP11B1 , GSH
    Susceptibility to aldosterone-producing adenoma (APA)
    Variant & Polymorphism other
  • -344 C/T and intron 2 conversion associated with markers of impaired 11beta-hydroxylase activity
  • rs6410 most frequent in patients with aldosterone-producing adenoma (APA) (Zhang 2010)
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS