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FLASH GENE
Symbol TUSC3 contributors: mct - updated : 16-01-2019
HGNC name tumor suppressor candidate 3
HGNC id 30242
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 splicing 3888 39 348 - 2000 10673282
10 splicing 3823 - 347 - 2000 10673282
11 - 4092 - 348 - 2000 10673282
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon  
 liver   highly
Endocrinepancreas   highly
Hearing/Equilibriumearinnercochlea highly
Nervousbrain    
Reproductivemale systemprostate  highly
Respiratorylung   highly
Urinarybladder   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularexocrine 
cell lineage
cell lines
fluid/secretion
at STAGE
Text brain
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a membrane-anchored N-terminal thioredoxin domain located in the ER lumen that may form transient mixed disulfide complexes with DDOST substrates
  • four transmembrane domains (4TM)
  • HOMOLOGY
    interspecies homolog to rattus Lag2
    Homologene
    FAMILY OST3 family
    CATEGORY tumor suppressor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text localizes to the endoplasmic reticulum
    basic FUNCTION
  • putative prostate cancer tumor supressor
  • catalyzes the transfer of an oligosaccharide chain on nascent proteins, the key step of N-glycosylation
  • STK11, TP53, TUSC3 might play a role in the development of metastasis in larynx and pharynx squamous cell carcinomas (
  • MAGT1 and TUSC3 are indispensable members of the vertebrate plasma membrane Mg(2+) transport system
  • required for cellular Mg2+ uptake )
  • play a central role in vertebrate embryonic development that cannot be compensated by other putative Mg2+ transporters
  • role for N-glycosylating events in ovarian cancer pathogenesis and TUSC3 is a tumor suppressor gene in ovarian cancer in particular
  • functions in final steps of N-glycosylation of proteins, while its loss evokes the unfolded protein response
  • possible role of TUSC3 beyond endoplasmic reticulum
  • may act as an oncogene in the progression of colorectal cancer
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TUSC3 induces autophagy in non-small cell lung cancer cells through activation of the Wnt/CTNNB1 signaling pathway
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MRAR5
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   deletion    
    in prostate cancer
    tumoral     --over  
    in papillary thyroid carcinoma
    tumoral     --low  
    in grade 3 tumors compared with tumors of lower grade
    tumoral     --low  
    in several ovarian cancer cell lines
    constitutional       loss of function
    inactivation through methylation of TUSC3 and ESR1 associated with ulcerative colitis, but not with colrectal carcinoma
    tumoral     --low  
    in hepatocellular carcinoma
    tumoral     --low  
    in esophageal squamous carcinoma
    Susceptibility prostate cancer
    Variant & Polymorphism SNP
    Candidate gene
    Marker
  • has potential to be used as prognostic markers in Colorectal Cancer
  • could be used as an independent predictor of prognosis in hepatocellular carcinoma patients
  • decreased immunological TUSC3 staining is a factor prognostic of poor survival in pancreatic cancer patients and decreased TUSC3 promotes pancreatic cancer cell proliferation, invasion and metastasis
  • Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivecolon
    has potential to be used as therapeutic targets in CRC
    ANIMAL & CELL MODELS