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FLASH GENE
Symbol PMP2 contributors: SGE/npt - updated : 31-05-2010
HGNC name peripheral myelin protein 2
HGNC id 9117
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 3579 - 132 - Hayasaka (1991)
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrainlimbic systemhippocampus  
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervouscentralwhite matter  
Nervousperipherous   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES basic
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Pmp2 (87.1pc)
homolog to rattus Pmp2 (90.2pc)
Homologene
FAMILY
  • calycin superfamily
  • fatty-acid binding protein (FABP) family
  • CATEGORY structural protein , transport
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • potentially involved in the transport of fatty acids or metabolism of myelin lipids
  • acting synergistically with MBP to cause stacking of lipid bilayers (Suresh 2010)
  • lipid binding activity (Hayasaka 1991)
  • may play a role in lipid transport protein in Schwann cells
  • forms a beta-barrel structure that accomodates hydrophobic ligand in its interior
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text lipid transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism SNP
  • SNP at positions 220 and 445 (Besanšon 2001)
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS