protein
| CSTF1 and repressing nuclear mRNA polyadenylation (linking mRNA 3' end formation to DNA damage and tumor suppression) |
|
RNA polymerase II holoenzyme |
|
BRCA1 for mediating of protein ubiquitination |
|
interaction with TP53( TP53 dependent role in apoptosis) |
|
UBXN1 associates with autoubiquitinated BRCA1/BARD1 heterodimers in a bipartite manner (interaction between NR5A1 and BRCA1/BARD1 may recruit BRCA1/BARD1 complex to the aromatase PII promoter for BRCA1/BARD1-mediate transcriptional repression) |
|
BRCA1/BARD1 complex interacts with NR5A1  |
|
BRCA1 functions depend on the interaction with BARD1 for its stability, nuclear localization and ubiquitin ligase activity  |
|
BRCA1 heterodimerizes with its partner protein, BARD1, via the RING domain present in both proteins  |
Other morbid association(s)
|
Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
---|
tumoral
| germinal mutation
|  
|  
|  
|
in breast and breast-ovarian cancers | tumoral
|  
| deletion
|  
|  
|
homozygous deletion, in basal breast cancer  | tumoral
| germinal mutation
|  
|  
| loss of function
|
in patients with primary ovarian, fallopian tube, or peritoneal cancers  | |