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FLASH GENE

Symbol

SERPINB9

contributors: mct - updated : 08-03-2008

HGNC name	serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 9
HGNC id	8955

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 7 - 4121 - 376 - Kummer (2007)

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular vessels         Digestive salivary gland       highly Lymphoid/Immune lymph node       highly Reproductive female system ovary         female system placenta     highly   male system testis       Respiratory lung         Visual eye

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow       Connective bone       Epithelial barrier/lining

cells

System Cell Pubmed Species Stage Rna symbol Cardiovascular endothelial cell Lymphoid/Immune lymphocyte

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

intraspecies

homolog to highly,to the genes of the serpin cluster on chromosome 18 (SPI@2)

Homologene

FAMILY

serpin family, ovalbumin subgroup

CATEGORY

enzyme , regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic

basic FUNCTION	can regulate pro-apoptotic apical caspases
	potent inhibitor of GZMB, and protects testicular Sertoli cells and placental syncytial trophoblasts from GZMB-producing auto- or allo-reactive cytotoxic lymphocytes

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	inhibited apoptotic death by directly interacting with the intermediate active forms of caspase-8 and -10
	potent inhibitor of the cytotoxic lymphocyte (CL) proteinase granzyme B, a major effector molecule used by CLs to induce target cell apoptosis

cell & other

REGULATION

inhibited by

GZMM

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   in gestational trophoblastic diseases contributes to disease pathogenesis via immune evasion

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS