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FLASH GENE

Symbol

RFK

contributors: npt/ - updated : 04-01-2010

HGNC name	riboflavin kinase
HGNC id	30324

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_018339 4 - 2707 NP_060809 - 155 - Yazdanpanah (2009)

EXPRESSION

Type

expressed in	(based on citations)
organ(s)

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic

basic FUNCTION	riboflavin kinase activity
	catalyzing the phosphorylation of riboflavin (vitamin B2) to form FMN, an obligatory step in vitamin B2 utilization and flavin cofactor synthesis (Karthikeyan 2003)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

binds to both the TNFRSF1A-death domain and to p22(phox), the common subunit of NADPH oxidase isoforms (Yazdanpanah 2009)

cell & other

REGULATION

activated by

TNF (TNF, through the activation of RFK, enhances the incorporation of FAD in NADPH oxidase enzymes, a critical step for the assembly and activation of NADPH oxidase) (Yazdanpanah 2009)

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS