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FLASH GENE
Symbol PYGO2 contributors: mct - updated : 22-06-2011
HGNC name pygopus homolog 2 (Drosophila)
HGNC id 30257
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 3227 - 406 - -
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivestomach   moderately
Lymphoid/Immunespleen   moderately
Reproductivefemale systemuteruscervix highly
 female systembreastmammary gland moderately
 female systemovary  moderately
Urinarybladder   predominantly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscular    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a PHD-type zinc finger
  • a critical domain encompassing the first 47 AAs that mediates its HMT/HAT interaction
  • mono polymer complex
    HOMOLOGY
    interspecies homolog to drosophila pygo
    homolog to murine Pygo2
    Homologene
    FAMILY
    CATEGORY regulatory , transcription factor , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text
  • nucleus-cytoplasm shuttling proteins that are retained in the nucleus in response to calcium-mediated signaling and alpha-calcium/calmodulin-dependent kinase protein II (CaMKII) activity
  • basic FUNCTION
  • involved in signal transduction through the Wnt pathway
  • playing a role in the regulation of transcription, DNA-dependent
  • required for cell regulation in the absence of Wnt signaling
  • role in histone modification linked to its enhancement of the Wnt-dependent transcriptional program and cancer stem-like cell expansion
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    Wnt pathway
    a component
  • component of the T-cell factor/beta-catenin transcriptional complex essential for activation of Wnt target genes
  • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • BCL9 via the PHD-type zinc finger motif
  • associates with histone-modifying enzymatic complexes, specifically the MLL2 histone methyltransferase (HMT) and STAGA histone acetyltransferase (HAT) complexes, to facilitate their interaction with beta-catenin
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in a high proportion of breast and epithelial ovarian malignant tumors and is required for the growth of several cell lines derived from these carcinomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS