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FLASH GENE
Symbol PRRG3 contributors: - updated : 03-06-2005
HGNC name proline rich Gla (G-carboxyglutamic acid) 3 (transmembrane)
HGNC id 30798
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Nervousbrain   moderately
Reproductivefemale systembreastmammary gland lowly
 female systemovary  lowly
 male systemprostate  moderately
Visualeye   lowly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES Hydrophobic
STRUCTURE
motifs/domains
  • a gamma-carboxy-glutamate domain (Gla) domain
  • 13 potential Gla residues (Gla residues are produced after subsequent posttranslational modifications of glutamate by a vitamin K-dependent gamma- carboxylase)
  • membrane-spanning hydrophobic regions
  • cytoplasmic carboxyl terminal regions containing PPXY motifs
  • HOMOLOGY
    interspecies ortholog to murine Gm368
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type I membrane protein
    basic FUNCTION unknown
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    Ca2+
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS