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FLASH GENE
Symbol H2AFV contributors: - updated : 15-04-2005
HGNC name H2A histone family, member V
HGNC id 20664
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- splicing 1153 13 128 - Sulston
  • encoding the longest protein
  • - splicing 825 12 114 - Sulston
  • utilizing an alternate exon in the 3' coding region and 3' UTR compared to variant 1
  • - splicing 1075 11 102 - Sulston
  • lacking an internal exon in the coding region compared to variant 1
  • - splicing 1023 - 66 - Sulston
  • lacking a 3' exon in the coding region compared to variant 1
  • - splicing 1039 9 90 - Sulston
  • lacking an internal exon in the coding region compared to variant 1
  • EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Lymphoid/Immunelymph node   highly
     thymus   predominantly
    Urinarykidney   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES basic
    STRUCTURE
    motifs/domains
    mono polymer heteromer , octamer
    HOMOLOGY
    interspecies homolog to murine H2afv
    ortholog to xenopus Xl.24058
    Homologene
    FAMILY member of the histone H2A family
    CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome,nucleosome
    basic FUNCTION
  • playing a role in the compaction of DNA into nucleosomes
  • CELLULAR PROCESS nucleotide, chromatin organization, remodeling
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • core histone H2A/H3B/H3/H4 (nucleosome)
  • INTERACTION
    DNA binding approximatively 0.146 kb
    RNA
    small molecule
    protein
  • H2A
  • H3B
  • H3
  • H4
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS