basic FUNCTION
| playing a role in activation of IL-6 production |
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absolutely required for expression of the pluripotent pro-inflammatory cytokine interleukin-6 in peritoneal macrophages (T |
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functions as an additional regulator of NF-kappaB activity and, hence, provides another control level for the activation of NF-kappaB-dependent target genes |
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essential for the activation of NK cells and antiviral host defense responses |
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required for the activation of NK cells in response to IL12B and IL18 |
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plays an essential role in the activation of NK cells by triggering dynamic transcription factor recruitment and chromatin remodeling |
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functions as an important regulator of IFNG in human NK cells, further expanding the class of NFKBIZ-modulated genes |
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distinguished role of NFKBIZ in mediating the targeted recruitment of monocytes in response to local inflammatory events |
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critical roles for NFKBIZ in TLR signaling in B cells |
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essential role of NFKBIZ in regulating a specific set of NFKB1 target genes |