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FLASH GENE

Symbol

PRRG1

contributors: - updated : 08-05-2004

HGNC name	proline-rich Gla (G-carboxyglutamic acid) polypeptide 1
HGNC id	9469

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain diencephalon hypothalamus       nerve cranial nerve optic nerve       spinal cord

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo, pregnancy

Text	placenta, trabecular meshwork

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a 20-amino acid propeptide that contains the highly conserved residues implicated in gamma-carboxylation
	a N-terminal Gla domain
	a transmembrane region and
	a proline-rich C-terminal region that contains PPXY and PXXP motifs, which are found in proteins that interact with WW domains and SH3 domains, respectively

HOMOLOGY

Homologene

FAMILY

transmembrane gamma-carboxyglutamic acid protein 1 family

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	extracellular
	plasma membrane

basic FUNCTION

having calcium ion binding activity

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS