Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol PDZD3 contributors: - updated : 26-09-2007
HGNC name PDZ domain containing 3
HGNC id 19891
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon highly
 intestinesmall intestineileum  
 intestinesmall intestinejejunumcrypt of Lieberkuhn 
 intestinesmall intestineduodenum  
Urinarykidney   lowly
cells
SystemCellPubmedSpeciesStageRna symbol
Digestiveepithelial cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four PDZ/DHR domains
  • among which PDZ domain 3 binds with Na-phosphate cotransporter IIa and and PDZ domain 4 with TRPV6
  • HOMOLOGY
    interspecies ortholog to murine Pdzk2
    Homologene
    FAMILY superfamily of class I PDZ proteins
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • may inhibit the catalytic activity of GCC by binding to its COOH terminal
  • essential TRPV6 interacting protein as a physiological modulator of TRPV6
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • GCC binding
  • interacts with TRPV6 through its fourth PDZ domain
  • interacts with Na-phosphate cotransporter IIa and induced endocytosis of Na-phosphate cotransporter IIa, which in turn result in Na and phosphate excretion in the urine
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS