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FLASH GENE

Symbol

ZNF444

contributors: mct/npt - updated : 10-03-2010

HGNC name	zinc finger protein 444
HGNC id	16052

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_018337 5 - 2059 NP_060807 - 327 - Adachi (2002)

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune spleen         Reproductive female system uterus         female system placenta       Respiratory lung

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	four C2H2-type zinc fingers
	a SCAN box domain

HOMOLOGY

interspecies

homolog to rattus LOC292569

Homologene

FAMILY

Krueppel C2H2-type zinc finger protein family

CATEGORY

regulatory , transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION

regulates the gene encoding the scavenger receptor expressed by endothelial cells, by binding to the 5'flanking critical region of the SCARF1 promoter

CELLULAR PROCESS

nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

binding

RNA

small molecule	metal binding,
	ion Zn2+

protein

binds to the 5prime-flanking critical region of the SCARF1 promoter activity and increases its promoter activity (Adachi 2002)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral fusion       t(19;22)(q13;q12) leading to the novel fusion gene EWSR1-ZNF444 in soft tissue myoepithelial carcinoma (Brandal 2009)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS