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FLASH GENE
Symbol SOCS6 contributors: mct - updated : 08-02-2016
HGNC name suppressor of cytokine signaling 6
HGNC id 16833
RNA
TRANSCRIPTS type messenger
text two SOCS6 transcripts were generated from the major transcription initiation site due to the usage of the two alternative polyadenylation sites (PMID: 19716864)
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 5846 59.5 535 - 2009 19716864
- - 2919 59.5 535 - 2009 19716864
EXPRESSION
Rna function skeletal muscle, placenta, tongue
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   moderately
Digestivesalivary gland   highly
 stomach   moderately
Endocrineparathyroid   highly
 thyroid   moderately
Urinarykidney   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticmature hematopoietic
Skin/Tegumentmelanocyte
cell lineage
cell lines factor independent CML, erythroleukemia
fluid/secretion
at STAGE
physiological period embryo, pregnancy
Text umbilical cord, embryonic tissue
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal amino acids 1-210 sufficient to locate the protein into the nucleus solitary in both the cytoplasm and the nucleus, and the KID domain (AA 47–218) provides an interface for binding the kinase domain of LCK
  • a central Src homology SH2 domain
  • at least two functional domains required for its biological role in localizing and degrading STAT3 in the nucleus
  • a C terminal conserved SOCS box, acting as a common binding domain for a large family of E3 ubiquitin protein ligases
  • an SH2 domain, in the cytoplasm
  • HOMOLOGY
    interspecies homolog to rattus Socs6 (84.91 pc)
    homolog to murine Socs6 (85.66 pc)
    Homologene
    FAMILY
  • SOCS protein family
  • CIS family
  • CATEGORY regulatory , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text
  • primarily located and regulated in the cytoplasm, and in the nucleus
  • localizes to the nucleus where it reduces STAT3
  • basic FUNCTION
  • part of a classical negative feedback system that regulates cytokine signal transduction
  • having a putative function as a negative regulator of receptor tyrosine kinases
  • having at least two functional domains required for its biological role in localizing and degrading STAT3 in the nucleus
  • negative regulator of cytokine signaling pathways
  • negative regulator of LCK
  • in response to TCR stimulation, associates with and negatively regulates LCK
  • important role for SOCS6 in cellular homeostasis
  • acting as a negative regulator of T cell activation by promoting ubiquitin-dependent proteolysis
  • CELLULAR PROCESS nucleotide, transcription, regulation
    protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to elongin B and C through its SOCS box
  • interacting with IRS4 and IRS2
  • binds to KIT juxtamembrane region, which affects upstream signaling components leading to MAPK activation
  • interacts with RBCK1, a type of E3 ubiquitin ligase involved in proteasome-mediated degradation
  • targeting LCK to proteasome-dependent degradation in response to T cell activation and negative regulation of LCK by SOCS6 may in part prevent uncontrolled T cell activation
  • SOCS6 negatively regulates FLT3 activation, the downstream Erk signaling pathway, and cell proliferation
  • by terminating RELN signaling, SOCS6 and SOCS7 may allow new cycles of RELN signaling to occur and these may be essential for cortical neuron migration
  • cell & other
    REGULATION
    induced by induced by erythropoietin (EPO) and granulocyte macrophage CSF (CSF2) in hematopoietic cell lines
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   LOH    
    frequent event in gastric tumorigenesis
    tumoral     --low  
    in carcinomas of stomach and colon
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS