protein
| binding to elongin B and C through its SOCS box |
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interacting with IRS4 and IRS2 |
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binds to KIT juxtamembrane region, which affects upstream signaling components leading to MAPK activation |
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interacts with RBCK1, a type of E3 ubiquitin ligase involved in proteasome-mediated degradation |
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targeting LCK to proteasome-dependent degradation in response to T cell activation and negative regulation of LCK by SOCS6 may in part prevent uncontrolled T cell activation |
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SOCS6 negatively regulates FLT3 activation, the downstream Erk signaling pathway, and cell proliferation |
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by terminating RELN signaling, SOCS6 and SOCS7 may allow new cycles of RELN signaling to occur and these may be essential for cortical neuron migration |