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FLASH GENE

Symbol

EPS8L3

contributors: mct - updated : 26-06-2019

HGNC name	EPS8-like 3
HGNC id	21297

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_139053 19 - 2222 NP_620641 - 594 - 2014 24236410 NM_133181 19 - 2219 NP_573444 - 593 - 2014 24236410 NM_024526 19 - 2129 NP_078802 - 563 - 2014 24236410 NM_001319952 18 - 2077 NP_001306881 - 530 - 2014 24236410

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine large intestine colon       liver           stomach         Urinary kidney

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N terminal PTB domain
	C terminal SH3 domain

HOMOLOGY

interspecies

homolog to drosophila Aru

Homologene

FAMILY

EPS8 family

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm

basic FUNCTION	enhancing EGF-dependent mitogenic signals
	role of EPS8L3 in memory
	has a role in classically conditioned olfactory memory

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

might likely promote proliferation by hyperactivating the AKT1 signaling pathway and subsequently inhibiting the FOXO1 transcriptional activity

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

HMU2

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in hepatocellular carcinoma (HCC) tissues and cell lines compared with the normal liver tissues and cell lines

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer digestive liver may be a novel therapeutic target for HCC

ANIMAL & CELL MODELS