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FLASH GENE
Symbol SLC6A14 contributors: mct - updated : 22-08-2012
HGNC name solute carrier family 6 (neurotransmitter transporter), member 14
HGNC id 11047
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
14 - 4564 - 642 - 2008 18599538
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivepharynx    
 salivary gland    
 stomach    
Reproductivefemale systembreastmammary gland  
Respiratoryrespiratory tracttrachea   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated GlycoP
HOMOLOGY
Homologene
FAMILY Na(+)- and Cl(-)-dependent neurotransmitter transporter family
CATEGORY transport carrier
SUBCELLULAR LOCALIZATION     plasma membrane
text integral membrane protein
basic FUNCTION
  • transporting both neutral and cationic amino acids in an Na(+)- and Cl(-)-dependent manner
  • may play a role in regulation of glycine levels in NMDA receptor-mediated neurotransmission
  • encodes the transport protein known as the beta-alanine carrier which, due to its broad substrate specificity, is likely to play an important role in absorption of essential nutrients and drugs in the distal regions of the human gastrointestinal tract
  • transports 18 of the 20 proteinogenic amino acids
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction with Protein kinase C (regulation by PKC correlated with high activity of both proteins reported for cancer cells)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    specifically in estrogen receptor (ER)-positive breast cancer
    tumoral     --over  
    in colon cancer and cervical cancer
    Susceptibility to obesity
    Variant & Polymorphism SNP SNP 22510 C>G at-risk G allele was associated, both in adult women with moderate obesity and in 234 obese girls, with higher body fat and modified perception of hunger and satiety
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductivebreast
    novel and effective drug target for the treatment of ER-positive breast cancer
    ANIMAL & CELL MODELS