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FLASH GENE

Symbol

RNF216

contributors: mct/npt - updated : 06-12-2019

HGNC name	ring finger protein 216
HGNC id	21698

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_207111 17 - 5793 NP_996994 - 923 - 2014 25484083 NM_207116 17 - 5622 NP_996999 99 866 - 2014 25484083

EXPRESSION

Type

expressed in	(based on citations)
organ(s)

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a double ring finger linked (DRIL) motif

HOMOLOGY

Homologene

FAMILY	zinc finger family
	ubiquitin ligase of the RING-in-between-RING family

CATEGORY

unknown/unspecified

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus,nucleoplasm

basic FUNCTION	E3 ubiquitin-protein ligase that interacts with the Toll/interleukin-1 receptor domain of TLRs and promotes their proteolytic degradation (Fearns 2006)
	versatile E3 ubiquitin ligase that negatively regulates RIG-like receptor signaling by targeting TRAF3 for degradation following RNA virus infection (Nakhaei 2009)
	appear to be involved in the movement of TLR4 to the lysosome for degradation (McGettrick 2010)
	RNF216 is a key negative regulator of sustained KIR2DL4-mediated NFKB1 signaling from internalized KIR2DL4, which functions by promoting ubiquitylation and degradation of endocytosed receptor from early endosomes
	RNF216 promoted Colorectal cancer cell proliferation and migration by negatively regulating BECN1-dependent autophagy
	is an E3 ubiquitin ligase that recognizes and facilitates the ubiquitination of its target for degradation by the ubiquitin-proteasome system (UPS)
	essential function of RNF216 in spermatogenesis and male fertility, suggesting a critical role for RNF216 in human gonadal development
	RNF216 regulates the migration of GNRH1 neuron by suppressing BECN1 mediated autophagy, suggesting a potential contribution of autophagy to the hypogonadotropic hypogonadism

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	E3 ubiquitin-protein ligase to RIPK1 and Hsp90 and RNF216 cooperatively maintain the homeostasis of RIPK1 (Fearns 2006)
	RNF216 is an interaction partner for the KIR2DL4 cytoplasmic domain
	RNF216 interacts with BECN1, a key regulator in autophagy, and leads to ubiquitination of BECN1, thereby contributing to BECN1 degradation
	TLR8 proteasomal disposal through RNF216 in response RNA ligands regulate TLR8 cellular concentrations and may have implications innate immune signaling

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

GDHS

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	potential biomarker for inhibiting colorectal cancer (CRC development and progression
Therapy target
	System Type Disorder Pubmed cancer digestive colon therapeutic target for inhibiting CRC development and progression immunology inflammatory   may be a target for treatment of inflammatory diseases

ANIMAL & CELL MODELS