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FLASH GENE
Symbol AKAP8L contributors: mct - updated : 24-08-2011
HGNC name A kinase (PRKA) anchor protein 8-like
HGNC id 29857
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
14 - 2136 - 646 - 2007 17594903
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text pancreas
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • potential nuclear localization signal
  • two C2H2 tyep zinc finger motifs
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text
  • shuttles between nucleus and cytoplasm
  • localized to the nucleus in interphase, where it primarily associates with the nuclear matrix
  • basic FUNCTION
  • playing a role in constitutive transport element(CTE)- medated gene expression
  • role in DNA replication by providing a scaffold for MCM2
  • having a ubiquitin ligase activity and may be involved in cell growth control potentially through the interaction with AKAP8L
  • CELLULAR PROCESS protein
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • C-terminus of RNA-helicase A
  • interacting with PRPF40A (AKAP8L/PRPF40A scaffold is a potential nuclear docking site for huntingtin protein and may contribute to the nuclear accumulation of huntingtin observed in Huntington disease)
  • RNF43-interacting protein
  • nuclear PRKACA, and PRKACB co-locates with AKAP8L in SFCs (splicing factor compartments) and regulates pre-mRNA splicing, possibly through a cAMP-independent mechanism
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS