basic FUNCTION
| involved in regulating response to cytokines by members of the REL/NFKB transcription factor family in response to pathogens |
|
recruited to CD40 and TNFRSF13B indirectly, which is mediated by TRAF3 through the TRAF binding site in TRAF3IP2 ( |
|
modulates the survival of autoreactive B cells mainly through its negative regulatory role in TNFSF13B-mediated cell survival |
|
essential adaptor molecule in IL17-mediated signaling and is recruited to the IL17 receptor (IL17R) upon IL17 stimulation through an interaction between its SEFIR domain and that of the IL17R |
|
mediates IL17-induced signaling pathways through its E3 ubiquitin ligase activity |
|
essential role of epithelial-derived TRAF3IP2 in allergic pulmonary inflammation through the distinct impact of the IL17R-TRAF3IP2 and IL25R-TRAF3IP2 axes ( |
|
plays a critical role in the regulation of transitional B cell survival and maturation |
|
negative regulator of TNFSF13B-mediated signaling |
|
regulates TNFSF13B responsiveness and self-reactive B cell selection during transitional B cell maturation |
|
involved in IL17 signaling and which interacts with members of the REL/NF-KB transcription factor family ( |
|
|
|
negatively regulates B-cell survival through its interaction with TRAF3 |
|
signaling adaptor involved in the regulation of adaptive immunity |
|
|