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FLASH GENE

Symbol

KLHL22

contributors: mct - updated : 03-09-2011

HGNC name	kelch-like 22 (Drosophila)
HGNC id	25888

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	54.36 kb     7 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_032775 7 - 2637 - 634 - 2009 19995937

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive salivary gland         Nervous nerve         Reproductive female system ovary         male system prostate       Respiratory respiratory tract larynx

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective adipose

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	one BTB(POZ) domain
	six Kelch repeats

HOMOLOGY

interspecies

homolog to murine Klhl22 (94.3pc)

Homologene

FAMILY

CATEGORY

DNA associated

SUBCELLULAR LOCALIZATION

basic FUNCTION

unknown

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

KLHL21 and KLHL22, interact with CUL3 and are required for efficient chromosome alignment

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS