SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,cytosolic,vesicle
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| intracellular,cytoplasm,cytoskeleton,microtubule
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text
| EHD1 and EHD3 localize to preciliary membranes and the ciliary pocket |
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resides in tubular and vesicular membrane structures and participates in endocytic recycling |
basic FUNCTION
| participating in the clathrin-mediated endocytic machinery |
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also potentially involved in signal transduction pathways, downsteam of receptor tyrosine kinases |
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regulates microtubule-dependent movements of endocytic tubular ans vesicular structures |
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having a function in early endosome to endocytic recycling compartment transport |
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regulates transport from the early endosome to the recycling endosome (George 2007) |
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colocalize with vesicular and tubular structures, implying roles in transport processes and cytoskeletal dynamics and interact with specific phospholipids (Blume 2007) |
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role for EHD3 in regulating endosome-to-Golgi transport, and as a consequence, lysosomal biosynthetic, but not secretory, transport pathways are also affected |
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critical mediator of membrane protein trafficking in the heart |
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is a previously unrecognized component of the cardiac remodeling pathway |
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the functions of both EHD1 and EHD4 are primarily in tubular recycling endosomes (TREs) membrane vesiculation, whereas EHD3 is a membrane-tubulating protein |
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functions as a tumor suppressor gene and loss of its expression is a very common event in gliomas |
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is a critical component of protein trafficking in heart and is essential for the proper membrane targeting of select cellular proteins that maintain excitability |
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EHD1 and EHD3 reorganize the M-centriole and associated distal appendage vesicles (DAVs) before coordinated ciliary membrane and axoneme growth |
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CACNA1G, CACNA1H are substrates for EHD3-dependent protein trafficking in heart, implicating EHD3 as a key player in the regulation of atrial myocyte excitability and cardiac conduction |
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EHD1 and EHD3 control traffic to the endocytic recycling compartment (ERC) and from the ERC to the plasma membrane, while EHD2 modulates internalization |