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FLASH GENE
Symbol ONECUT2 contributors: mct - updated : 08-06-2013
HGNC name one cut domain, family member 2
HGNC id 8139
DNA
TYPE functioning gene
STRUCTURE 55.61 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 16142 - 504 - 2008 18418398
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   predominantly Homo sapiensFetal
Endocrinepancreas     Homo sapiensFetal
Nervousspinal cordanterior horn    Homo sapiensFetal
Visualeyeretina    Mus musculusFetal
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervouscentral    Homo sapiensFetal
Nervousperipherous    Homo sapiensFetal
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a polyglutamine tract,a STP box,a polyhistidine tract,
  • a Drosophila cut-like and a peculiar helix-turn-helix (homeo) -DNA binding domain
  • HOMOLOGY
    intraspecies paralog to ONECUT1, ONECUT3
    Homologene
    FAMILY Onecut (OC) family of transcription factors
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • required for liver differnetiation and metabolism
  • participating to the control of organ development from the forgut and midgut endoderm
  • ONECUT2 and ONECUT3 play redundant roles with ONECUT1 in pancreas development
  • ONECUT1, ONECUT2, ONECUT3 are required at early developmental stages for differentiation of the mesencephalic trigeminal nucleus neurons that are in turn necessary for maintenance of the Locus Coeruleus
  • CELLULAR PROCESS cell cycle, checkpoint
    nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • direct target gene of TBX21 (TBX21 transactivates ONECUT2 transcription through putative TBX21 half-sites locating -451 to -347 of OC2 promoter region)
  • ONECUT1 and ONECUT2 transcription factors are the missing hemophilia B Leyden regulators that operate through the -5/-6 site
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS