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FLASH GENE
Symbol SIX6 contributors: - updated : 25-08-2005
HGNC name sine oculis homeobox homolog 6 (Drosophila)
HGNC id 10892
DNA
TYPE functioning gene
STRUCTURE 2.00 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked Y status provisional
Map cen - D14S1038 - SIX4 - D14S1166 - D14S1159 - SIX1 - SIX6 - D14S997 - qter
Authors Gallardo (99)
Physical map
LOC387990 14 similar to TIMM9 TIMM9 14q22.3-q24 translocase of inner mitochondrial membrane 9 homolog (yeast) KIAA0586 14q23.1 KIAA0586 HSBP1P1 14 heat shock factor binding protein 1 pseudogene 1 HNRPCP 14 heterogeneous nuclear ribonucleoprotein C pseudogene DACT1 14q22.3 dapper homolog 1, antagonist of beta-catenin (xenopus) LOC387991 14 similar to ribosomal protein L31 LOC390482 14 similar to Aldo-keto reductase family 1, member B1 PPIAP5 14 peptidylprolyl isomerase A (cyclophilin A) pseudogene 5 DAAM1 14q22.3 dishevelled associated activator of morphogenesis 1 GPR135 14q23.1 G protein-coupled receptor 135 FLJ25436 14q23.1 hypothetical protein FLJ25436 C14orf100 14q22.3 chromosome 14 open reading frame 100 RTN1 14q21-q22 reticulon 1 FLJ46156 14q23.1 FLJ46156 protein C14orf135 14q23.1 chromosome 14 open reading frame 135 DHRS7 14q23.1 dehydrogenase/reductase (SDR family) member 7 PSMA3P 14 proteasome (prosome, macropain) subunit, alpha type, 3 pseudogene PPM1A 14q22.3-q23.1 protein phosphatase 1A (formerly 2C), magnesium-dependent, alpha isoform RBM8B 14q22.1-q22.3 RNA binding motif protein 8B pseudogene C14orf39 14q23.1 chromosome 14 open reading frame 39 LOC390483 14 similar to sal-like 4 SIX6 14q22.3-q23 sine oculis homeobox homolog 6 (Drosophila) LOC387992 14 LOC387992 SIX1 14q22-q23 sine oculis homeobox homolog 1 (Drosophila) SIX4 14q23 sine oculis homeobox homolog 4 (Drosophila) MNAT1 14q23 menage a trois 1 (CAK assembly factor) MAD2L1P 14 MAD2 mitotic arrest deficient-like 1 (yeast) pseudogene SRMP2 14 spermidine synthase pseudogene 2 SLC38A6 14q23.1 solute carrier family 38, member 6 LOC161291 14q23.1 hypothetical protein LOC161291 PRKCH 14q22-q23 protein kinase C, eta HIF1A 14q21-q24 hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) SNAPC1 14q22 small nuclear RNA activating complex, polypeptide 1, 43kDa LOC122867 14q23.1 similar to cytochrome c oxidase subunit IV (COXIV) pseudogene (E.C. 1.9.3.1) MOCS3P 14 molybdenum cofactor synthesis 3 pseudogene SYT14L 14q23.2 synaptotagmin XIV-like LOC390484 14 similar to ATP synthase alpha subunit
regionally located closely linked to SIX1 and SIX4
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
endocrinebraindiencephalonpituitary  
Nervousbraindiencephalonhypothalamus  
 nervecranial nerveoptic nerve  
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Nervouscentral   
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousastrocyte
Nervousoligodendrocyte
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal, pregnancy
Text developing retina
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • six homeodomains
  • a helix-turn-helix DNA (homeo) binding domain
  • HOMOLOGY
    interspecies homolog to Drosophila sine oculis homeo box SIX6
    ortholog to murine Six6
    homolog to C.elegans ceh-32
    ortholog to chick Optx2
    Homologene
    FAMILY sine oculis (SIX/SINE) family of homeodomain transcription factors
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION involved in eye development
    CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development , cellular trafficking transport
    text histogenesis and organogenesis
    PATHWAY
    metabolism
    signaling sensory transduction/vision
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) BAPA , DEL14Q22
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    mice deficient in the Six6 homeodomain factor (Li,2002)