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FLASH GENE
Symbol FHL3 contributors: npt/mct - updated : 20-10-2012
HGNC name four and a half LIM domains 3
HGNC id 3704
DNA
TYPE functioning gene
STRUCTURE 8.75 kb     6 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
Physical map
GRIK3 1p34.1 glutamate receptor, ionotropic, kainate 3 FLJ23231 1p34.2 hypothetical protein FLJ23231 FLJ11730 1p35.3-p33 hypothetical protein FLJ11730 SNIP1 1p34.2 Smad nuclear interacting protein DNALI1 1p35.1 dynein, axonemal, light intermediate polypeptide 1 HUMAUANTIG 1p34.2 nucleolar GTPase FLJ40906 1p34.2 hypothetical protein FLJ40906 FLJ20508 1p34.2 hypothetical protein FLJ20508 CDCA8 1p34.2 cell division cycle associated 8 FLJ33655 1p34.2 hypothetical protein FLJ33655 LOC391026 1 similar to actinin, alpha 4 LOC391027 1 similar to chromosome 14 open reading frame 138 FLJ31434 1p34.2 hypothetical protein FLJ31434 FLJ45459 1p34.2 FLJ45459 protein SF3A3 1p34.1 splicing factor 3a, subunit 3, 60kDa FHL3 1p34.2-p32.3 four and a half LIM domains 3 CGI-94 1p34.2 comparative gene identification transcript 94 POU3F1 1p34.1 POU domain, class 3, transcription factor 1 LOC343259 1p34.2 similar to 78 kDa glucose-regulated protein precursor (GRP 78) (Immunoglobulin heavy chain binding protein) (BiP) (Endoplasmic reticulum lumenal Ca(2+) binding protein grp78) RRAGC 1p34 Ras-related GTP binding C MYCBP 1p33-p32.2 c-myc binding protein GJA10 1p35-p34 gap junction protein, alpha 10, 59kDa RHBDL2 1p35.1 rhomboid, veinlet-like 2 (Drosophila) FLJ12666 1p34.2 hypothetical protein FLJ12666 NDUFS5 1p34.2-p33 NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase) MACF1 1p32-p31 microtubule-actin crosslinking factor 1
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 1662 31 280 - 2007 17389685
5 - 1486 - 172 - 2007 17389685
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunelymph node   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal predominantly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four cysteine-rich LIM/double finger motifs, and the second zinc finger motif in LIM4 was responsible for the auto-activation of FHL3
  • a half LIM, extra finger domain
  • HOMOLOGY
    interspecies homolog to murine Fhl3 and Fhl2
    homolog to Drosophila cg9959
    homolog to C.elegans f25h5.1a
    intraspecies homolog to fhl2
    Homologene
    FAMILY
  • four and a half LIM domain family of LIM protein
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • FHL3 association with MYOD1 may contribute to the regulation of MYOD-dependent transcription of muscle genes and thereby myogenesis
  • significant regulator of actin cytoskeletal dynamics in skeletal myoblasts
  • SOX15, FHL3 and FOXK1 function to coordinately regulate the myogenic progenitor cell population and skeletal muscle regeneration
  • regulates transactivation by a novel molecular mechanism, not through binding to HIF1A or EP300
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text muscle development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MYOD1-associated protein (functioning as its potent negative co-transcriptional regulator)
  • bound MZF1 (negatively regulates human high-affinity IgE receptor beta-chain gene expression by acting as a transcriptional co-repressor of MZF1)
  • FHL1, FHL2, and FHL3 physically and functionally interact with SMAD2, SMAD3, and SMAD4, important regulators of cancer development and progression, in a TGF-beta-independent manner
  • is a novel ANG binding partner (this interaction may provide some clues to the mechanisms of ANG-regulated cell growth and apoptosis)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS