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FLASH GENE
Symbol FHL3 contributors: npt/mct - updated : 20-10-2012
HGNC name four and a half LIM domains 3
HGNC id 3704
DNA
TYPE functioning gene
STRUCTURE 8.75 kb     6 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 1662 31 280 - 2007 17389685
5 - 1486 - 172 - 2007 17389685
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunelymph node   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal predominantly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four cysteine-rich LIM/double finger motifs, and the second zinc finger motif in LIM4 was responsible for the auto-activation of FHL3
  • a half LIM, extra finger domain
  • HOMOLOGY
    interspecies homolog to murine Fhl3 and Fhl2
    homolog to Drosophila cg9959
    homolog to C.elegans f25h5.1a
    intraspecies homolog to fhl2
    Homologene
    FAMILY
  • four and a half LIM domain family of LIM protein
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • FHL3 association with MYOD1 may contribute to the regulation of MYOD-dependent transcription of muscle genes and thereby myogenesis
  • significant regulator of actin cytoskeletal dynamics in skeletal myoblasts
  • SOX15, FHL3 and FOXK1 function to coordinately regulate the myogenic progenitor cell population and skeletal muscle regeneration
  • regulates transactivation by a novel molecular mechanism, not through binding to HIF1A or EP300
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text muscle development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MYOD1-associated protein (functioning as its potent negative co-transcriptional regulator)
  • bound MZF1 (negatively regulates human high-affinity IgE receptor beta-chain gene expression by acting as a transcriptional co-repressor of MZF1)
  • FHL1, FHL2, and FHL3 physically and functionally interact with SMAD2, SMAD3, and SMAD4, important regulators of cancer development and progression, in a TGF-beta-independent manner
  • is a novel ANG binding partner (this interaction may provide some clues to the mechanisms of ANG-regulated cell growth and apoptosis)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS