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FLASH GENE

Symbol

MRC2

contributors: - updated : 05-07-2005

HGNC name	mannose receptor, C type 2
HGNC id	16875

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	67.00 kb     30 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic         Connective         Epithelial barrier/lining epidermis     Epithelial barrier/lining endometrium

cells

System Cell Pubmed Species Stage Rna symbol Cardiovascular endothelial cell Lymphoid/Immune macrophage Muscular myoblast

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text

liver

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	large extracellular domain contains an N-terminal cysteine-rich domain
	type II fibronectin collagen-binding domain motif
	eight C type lectin-like carbohydrate recognition, a transmembrane domains
	a short cytoplasmic carboxyl terminus

conjugated

GlycoP

HOMOLOGY

interspecies

homolog to murine lectin lambda

Homologene

FAMILY

macrophage mannose receptor family

CATEGORY

receptor membrane

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	internalization of glycosylated ligands from the extracellular milieu
	may be regulating beta-glucan synthesis
	playing a physiological role in mediating collagen matrix remodelling during tissue development and homeostasis

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	metal binding,
	calcium Ca2+

protein	collagen V
	N-acetylglucosamine

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS