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FLASH GENE
Symbol PLP2 contributors: mct - updated : 23-05-2016
HGNC name proteolipid protein 2 (colonic epithelium-enriched)
HGNC id 9087
DNA
TYPE functioning gene
STRUCTURE 3.29 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 1049 16 152 - 2014 24604726
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrainhindbraincerebellum  
 brainlimbic systemhippocampus   Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Nervouspyramidal cell Homo sapiens
not specificgranular cell
cell lineage
cell lines differentially, in colonic epithelial cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four transmembrane segments (4TM)
  • a MARVEL domain
  • conjugated GlycoP , LipoP
    mono polymer homomer , polymer
    HOMOLOGY
    interspecies homolog to rattus Plp2 (84.1 pc)
    homolog to murine Plp2 (80.1 pc)
    Homologene
    FAMILY
  • integral membrane protein (proteolipids) family
  • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text integral membrane protein
    basic FUNCTION
  • play a role in cell differentiation in the epithelium
  • acting as an ion transmembrane transporter
  • critical function to PLP2 for viral ligase activity
  • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
  • chemotaxis
  • cytokine and chemokine mediated signaling pathway
  • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PLP2 (multimerize)
  • chemokine
  • physically interacting with CCT
  • CCR1
  • PLP2 binds specifically to PI3K, thus activating AKT1, and aids metastasis
  • PLP2 and RAB5C are novel TPD52 binding partners
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    directly promotes resistance to ER stressors
    Susceptibility to X-linked mental retardation (XLMR)
    Variant & Polymorphism SNP PLP2-(-113C>A) is sufficient to cause reduced expression and is enriched in a cohort of males with probable XLMR
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Plp2-deficient mice show increased neuronal death to ER stress and hypoxia in vitro and in a neonatal hypoxia-ischemia model