basic FUNCTION
| functioning as ESR1 corepressors (they directly interact with ESR1, and repress transcription via repression domains) |
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nuclear matrix protein that may couple chromatin structure, transcription, and RNA processing |
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may direct the reorganization and segregation of nuclear RNA and DNA prior to endonuclease-mediated DNA cleavage |
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like SAFB acts as a negative regulator of a TRA2B variable exon) |
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regulator of SRPK1 and SRPK2 activity underlining the importance of the assembly of transient intranuclear complexes in cellular regulation |
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major role in the activation of SREBF1 through its interaction with RBMX |
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involved in cell cycle regulation, apoptosis, differentiation, and stress response |
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role for SAFB1 in the regulation of immune genes and in estrogen-mediated repression of genes |
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nuclear matrix-associated protein that binds the scaffold or matrix attachment regions (S/MARs) of genomic DNA, as a novel TP53-interacting protein |
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multifunctional protein that binds both nucleic acids and is involved in the attachment of chromatin to the nuclear matrix, transcription, and stress response |
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SAFB and SAFB2 are nuclear matrix binding proteins that have been characterized as ESR1 corepressors |
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SAFB and SAFB2 are crucial repressors for ESR1 dynamics in association with the nuclear matrix and that their synergistic regulation of ESR1 mobility is sufficient for inhibiting ESR1 function |
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primarily associated with transcriptional repression, functions as a positive regulator of myogenic differentiation |
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contributes to the activation of skeletal muscle gene expression during myogenic differentiation by facilitating the transition of promoter sequences from a repressive chromatin structure to one that is transcriptionally permissive |
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undergoing a highly dynamic exchange at damaged chromatin in a PARP1- and poly(ADP-ribose)-dependent manner and is required for unperturbed cell-cycle checkpoint activation and guarding cells against replicative stress |
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chromatin scaffold protein SAFB1 renders chromatin permissive for DNA damage signaling |
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in addition to a role in basal cellular function in the brain, SAFB and SAFB2 proteins may serve as ESR1 corepressors in hormone-sensitive regions |
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