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FLASH GENE
Symbol MT1E contributors: mct/npt - updated : 13-03-2009
HGNC name metallothionein 1E
HGNC id 7397
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
STRUCTURE 1.44 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 519 5.88 61 - West (1990)
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   highly
Endocrineneuroendocrinepituitary  highly
Reproductivefemale systemovary  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated MetalloP
HOMOLOGY
Homologene
FAMILY
  • metallothionein superfamily
  • type 1 family
  • CATEGORY motor/contractile , storage
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • involved in multiple protective pathways including binding of toxic metals, free radical scavenging, and oxidative stress (Oppermann 2001)
  • having a necessary role for cancer cell migration (Wu 2008)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • heavy metal ions
  • protein
    cell & other
    REGULATION
    induced by heavy metal ions
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in bladder cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS