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FLASH GENE
Symbol LIM2 contributors: mct - updated : 25-10-2018
HGNC name lens intrinsic membrane protein 2, 19kDa
HGNC id 6610
DNA
TYPE functioning gene
STRUCTURE 8.00 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - splicing 970 24.5 215 - Wistow
- - splicing 860 19.7 173 - Wistow
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Visualeye   specific
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connective   lowly
cells
SystemCellPubmedSpeciesStageRna symbol
Visuallens fibers
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a four transmembrane segments (TM4)
  • mono polymer homomer , heteromer
    HOMOLOGY
    interspecies homolog to murine Lim2 (91.33 pc)
    homolog to rattus Lim2 (91.91 pc)
    Homologene
    FAMILY PMP22/EMP/MP20 family
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane,junction
    basic FUNCTION
  • water channel properties
  • contributing to cell junctional organization in both lens development and cataractogenesis
  • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • associated with itself or another lens membrane component via disulfide bonds
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CATPS
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS