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FLASH GENE
Symbol PRKAB1 contributors: mct/ - updated : 09-02-2010
HGNC name protein kinase, AMP-activated, beta 1 non-catalytic subunit
HGNC id 9378
DNA
TYPE functioning gene
STRUCTURE 13.67 kb     7 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 - 2412 - 270 - 1997 9224708
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinerectum  
 liver    
Lymphoid/Immunethymus    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer heteromer , trimer
HOMOLOGY
Homologene
FAMILY
  • 5'-AMP-activated protein kinase beta subunit family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • protein kinase, non catalytic subunit, involved in fatty acid and cholesterol metabolism
  • having a function that allows the regulation of proteasomal activity under conditions of energy demand
  • regulating cholesterol synthesis via phosphorylation and inactivation of hydroxymethylglutaryl-CoA reductase
  • and hormone- sensitive lipase
  • regulates the activation of TSC2 by phosphorylating TSC2
  • phosphorylating GFPT1 at Ser243 (has an important role in the regulation of the GFPT1 enzymatic activity)
  • may be implicated in the pathogenesis of chronic intestinal inflammatory conditions, such as inflammatory bowel disease
  • energy-sensing enzyme, counteracting energy depletion by stimulation of energy production and limitation of energy utilization
  • having a critical role in the survival of circulating erythrocytes
  • stimulates energy production and limits energy utilization
  • may act as a modulator in airway inflammation, such as acute lung injury or cystic fibrosis
  • implicated in modulation of glucose and fatty acid metabolism
  • induces MUC5B expression through the MAPK14 signaling pathway in airway epithelial cells
  • PRKAB1-induced MUC5B expression may be regulated through the MAPK14 signaling pathway in human airway epithelial cells
  • involved in the pathogenesis of Alzheimer disease
  • CAMKK2 and PRKAB1 function in a signaling pathway that participates in the regulation of adiposity
  • critical roles in regulating growth and reprogramming metabolism, and has recently been connected to cellular processes such as autophagy and cell polarity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism energetic , lipid/lipoprotein
    signaling
    STK11 and PRKAB1 family signaling: the intimate link between cell polarity and energy metabolism
    a component
  • heterotrimer of an alpha catalytic subunit, a beta and a gamma non-catalytic regulatory
  • downstream component of a protein kinase cascade that acts as an intracellular energy sensor maintaining energy balance within the cell
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with ADIPOQ and PTGS2 to protects the heart from ischemia-reperfusion injury
  • interaction of GRB2 with PRKAB1 (SH2 domain of GRB2 and KIS domain of PRKAB1 are both required and GRB2 function as a factor which mediates phosphorylation of PRKAB1 at Thr172)
  • PRKAA1, PRKAG1, PRKAB1 association with ULK1 plays an important role in autophagy induction, at least in part, by phosphorylation of raptor to lift the inhibitory effect of MTOR on the ULK1 autophagic complex
  • CAMKK2 can form a complex with and activate PRKAB1
  • cell & other
    REGULATION
    activated by cAMP
    phosphorylation at Thr172 that is catalysed by at least two distinct upstream kinases, i.e. the tumour suppressor STK11, and CAMKK2
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    accelerated cell proliferation and promoted malignant behavior such as increased cell migration and anchorage-independent growth in prostate cancer
    constitutional     --low  
    with the decreased expression of ACACA and overexpression of MLYCD are important regulators of the maturation of fatty acid oxidation in the newborn heart
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    immunologyinflammatory 
    may be an appropriate pharmacological target for control of mucus-hypersecretion in treatment of airway inflammatory diseases
    ANIMAL & CELL MODELS