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FLASH GENE

Symbol

SUMO3

contributors: mct - updated : 27-09-2023

HGNC name	SMT3 suppressor of mif two 3 homolog 1 (yeast)
HGNC id	11124

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	12.45 kb     4 Exon(s)

MAPPING

cloned

Y

linked

N

status

confirmed

Map	cen - PFKL PFKL - C21orf2 - D21S154 - D21S170 - D21S171 - D21S1903 - SUMO3 - ITGB2 - D21S1897 - ADARB1 - COL18A1 - SLC19A1 - D21S44 - D21S112 - COL6A1 - LSS - COL6A2 - PCNT2 - S100B - qter

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_006936 4 - 1831 NP_008867 - 103 - 2001 11451954 NM_001286416 4 - 1854 NP_001273345 - 141 - 2001 11451954

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       moderately Digestive stomach       moderately Reproductive female system uterus cervix   moderately   female system ovary     highly Skin/Tegument skin       moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow       Connective bone       Nervous peripherous

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a central ubiquitin domain
	a conserved C terminal Gly-Gly residues

HOMOLOGY

interspecies

ortholog to yeast S.cerevisiae SMT3 (suppressor of mutations in centromeric protein MIF2)

intraspecies	homolog to CENPC
	homolog to SUMO2 (97p100)

Homologene

FAMILY	ubiquitin family
	SUMO subfamily

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus,nucleoplasm,nuclear bodies,PML
	intracellular,nucleus,chromatin/chromosome,centromere
	intracellular,nucleus,chromatin/chromosome,kinetochore
text	SUMO-2/3 localize to centromeres and condensed chromosomes
	ARHGAP21 co-localizes with SUMO2/3 in the cytoplasm and membrane compartments

basic FUNCTION	involved in the function and/or structure of the eukaryotic kinetochore
	ubiquitin-like protein that can be conjugated to other proteins in a manner analogous to ubiquitination
	SUMO-2/3 conjugation and the ubiquitin-proteasome system are tightly integrated and act in a cooperative manner
	with other SUMO proteins, binding to lysine residues of target proteins and thereby modifying their stability, activity and subcellular localization
	with SUMO2 and SUMO1 accumulate at DNA double-strand breaks sites in mammalian cells, with SUMO1 and SUMO2/3 accrual requiring the E3 ligase enzymes PIAS4 and PIAS1
	SUMO2 and SUMO3 can rapidly convert to be conjugated in response to a variety of cellular stresses
	SUMO2 and SUMO3 are specific and essential negative regulators of a noncanonical mechanism of IFN induction

CELLULAR PROCESS

protein, degradation

PHYSIOLOGICAL PROCESS

cellular trafficking transport

PATHWAY

metabolism

signaling

a component

kinetochore

INTERACTION

DNA

RNA

small molecule

protein	targeting proteins
	covalently binding and modifying RANGAP1 involved in nuclear transport
	interacting with CENPE (CENPE was found to be modified specifically by SUMO-2/3 and to possess SUMO-2/3 polymeric chain-binding activity essential for kinetochore localization)
	EGLN3 SUMOylation by SUMO2 or SUMO3 contributes to EGLN3-mediated repression of HIF1-dependent transcriptional activity
	PES1 could be modified by the small ubiquitin-like modifier (SUMO) SUMO1, SUMO2 and SUMO3, and SUMOylation of PES1 was stimulated by estrogen (E2)
	SENP2 genetically interacts with SUMO2 and SUMO3 pivotal for the development of three major trophoblast layers
	SUMO3 modification of PIAS1 modulates AR cellular distribution and stability
	TRIM28 binds NLRP3, promotes SUMO1, SUMO2 and SUMO3 modification of NLRP3, and thereby inhibits NLRP3 ubiquitination and proteasomal degradation
	SUMO3 or SUMO3-modified proteins modulate likely the localization, stability, and RING ubiquitin ligase activity of TRIM55

cell & other

REGULATION

repressed by

expression of SUMO3, can be down-regulated at the transcription level by cellular oxidative stress

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS