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FLASH GENE

Symbol

CA1

contributors: mct - updated : 27-04-2018

HGNC name	carbonic anhydrase I
HGNC id	1368

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	49.94 kb     9 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

text	all variants encode the same protein

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001738 9 - 1278 NP_001729 28.74 261 - Gambhir (2007) NM_001128831 - - 1224 NP_001122303 28.74 261 - - NM_001128830 - - 1301 NP_001122302 28.74 261 - - NM_001128829 9 - 1299 NP_001122301 28.74 261 - - NM_001164830 9 - 1211 NP_001158302 - 261 - -

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine           stomach

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic erthrocyte

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

conjugated

MetalloP

isoforms

Precursor

HOMOLOGY

interspecies

homolog to car1

Homologene

FAMILY

alpha-carbonic anhydrase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic

basic FUNCTION	appear to be good markers for the differentiation of enterocytes in the colonic mucosa
	reversibly hydrating Co2 in cellular ion transport and Ph homeostasis

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	metal binding,
	Zn2+

protein

LDB1 forms a regulatory complex to maintain CA1 expression in erythroid cells

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   in erythrocytes of type II diabetic patients

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS