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FLASH GENE
Symbol PRSS1 contributors: mct/npt - updated : 26-08-2009
HGNC name protease, serine, 1 (trypsin 1)
HGNC id 9475
DNA
TYPE functioning gene
STRUCTURE 3.61 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Map see TCRB
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 821 - 247 - Yamamoto (1992)
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   highly
Endocrinepancreas   highly
Lymphoid/Immunethymus   highly
Urinarybladder   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text pancreas
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • 15 AA signal
  • 8 AA activation sites
  • HOMOLOGY
    interspecies homolog to murine Try1
    Homologene
    FAMILY
  • peptidase family S1 (trypsin family)
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • protease serine, cationic trypsinogen, playing a role in peptide linkages involving the carboxyl group of lysine or arginine
  • playing a role in the digestion
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS digestion
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PRSS2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) HPG
    related resource Database of genetic variants in patients
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional fusion     gain of function
    PRSS1/PRSS2, exons 1 and 2 are derived from PRSS2 and exons 3-5 from PRSS1, apparently resulted from a non-allelic homologous recombination, with double gain-of-function effect in chronic pancreatitis
    Susceptibility to chronic pancreatitis, to pancreatic cancer
    Variant & Polymorphism other mutation loss of function protecting against pancreatitis
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS