SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,endoplasmic reticulum
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| intracellular,cytoplasm,organelle,Golgi
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| intracellular,cytoplasm,organelle,endosome
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| intracellular,cytoplasm,cytosolic,vesicle
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| intracellular,nucleus
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text
| a fraction of VCP is localized to the early endosome membrane, where it binds EEA1 via the N-terminal C2H2 zinc finger domain  |
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SIK2 co-localizes with VCP in the ER membrane  |
basic FUNCTION
| homohexameric AAA (ATPase associated with a variety of activities) |
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vesicular transport and fusion |
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involved in the transfer of membranes from the endoplasmic reticulum to the golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum |
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implicated in a number of cellular events that are regulated during mitosis, including homotypic membrane fusion, spindle pole body function, and ubiquitin-dependent protein degradation |
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participating in a number of cellular processes including endoplasmic reticulum-associated degradation (ERAD) |
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multiubiquitin chain-targeting factor in the degradation of the ubiquitin-proteasome pathway |
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binding to an ubiquitylated form of Aurora B on chromatin, resulting in extraction of Aurora B from chromatin, allowing chromosome decondensation and nuclear envelope formation |
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essential biochemical component of a wide range of ubiquitin-linked cell biological reactions, including ubiquitin-proteasome system-mediated protein degradation, Golgi and endoplasmic reticulum (ER) membrane fusion, transcription factor activation, and DNA repair  |
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having functions in endocytic trafficking by establishing EEA1 as a new VCP substrate  |
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may regulate the size of early endosomes by governing the oligomeric state of EEA1  |
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cooperates with distinct cofactors to process ubiquitylated proteins in different cellular pathways  |
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cytosolic essential AAA chaperone, which regulates multiple cellular reactions in a ubiquitin-dependent manner  |
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important role in ubiquitin-dependent regulation of translesion synthesis |
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VCP is an important host factor in antiviral immunity  |
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VCP has a crucial role in proteasomal degradation of viral capsid  |
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is an essential cofactor for antibody-dependent intracellular neutralization (ADIN) and the ATPase activity of VCP is required when ADIN mediates proteasomal degradation of a challenging substrate such as an adenovirus particle  |
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has a crucial role in proteasomal degradation of viral capsid  |
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FAF2 and VCP play central integrative roles in cellular energy homeostasis  |
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acts downstream of ubiquitination and is required for transport of the ubiquitinated form of CAV1 to late endosomes  |
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conserved chaperone-like ATPase, plays a strategic role in the ubiquitin system  |
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AAA ATPase involved in protein turnover and degradation  |
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VCP-dependent protein extraction from chromatin has emerged as an essential evolutionarily conserved process for maintaining genome stability  |
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its depletion or pathogenic mutations reducing stress granule clearance in mammalian cells  |
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VCP and YOD1 are required in the downstream events of substrate deglycosylation and proteasomal degradation (  |
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important role for VCP in early autophagy initiation  |
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critical regulatory role of WIPI2 in mitochondrial recruitment of VCP to promote outer mitochondrial membrane protein degradation and eventual mitophagy  |
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involved in the fusion of early endosomes and endolysosomal degradation  |
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promotes not only the lysosomal degradation, but also the recycling of endocytic cargo  |
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ubiquitous AAA+ protein (ATPase associated with other activities) that facilitates protein degradation through the ubiquitin-proteasome and autophagy pathways  |