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FLASH GENE
Symbol CALM2 contributors: mct - updated : 14-05-2019
HGNC name calmodulin 2 (phosphorylase kinase, delta)
HGNC id 1445
DNA
TYPE functioning gene
STRUCTURE 16.85 kb     6 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 1210 - 149 - 2016 27516456
6 - 1236 - 113 - 2016 27516456
6 - 1377 - 197 - -
6 - 4591 - 197 - -
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivepharynx   highly
 salivary gland   highly
Endocrineneuroendocrinepituitary  highly
Urinarybladder   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains two Eps15 homology domains with four EF-hand calcium binding domains
HOMOLOGY
Homologene
FAMILY calmodulin family
CATEGORY enzyme , regulatory
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
intracellular,nucleus
basic FUNCTION
  • phosphorylase kinase, delta, calcium modulated protein
  • mediates the control of a large number of enzymes and other proteins by Ca(2+)
  • playing a crucial role in the processes of Ca(2+)-induced neuronal cell death and likely the blockage of calmodulin attenuates brain injury after cerebral ischemia
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    calcium Ca2+
    protein
  • interacts with TTN/titin and SRY
  • could regulate the intramolecular interaction between the SH3, HOOK, and GK domains of DLG1
  • interaction between RAB3B and calmodulin, Ca(2+)-dependent (RAB3B is primarily localized with the particulate fraction and Ca(2+)/calmodulin could regulate function of this GTPase in the platelet)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) LQT15
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    might represent an attempt by the placenta to compensate for elevations in intracellular calcium, possibly caused by hypoxia and/or apoptosis, in both pregnancies with uterine artery notching and preeclampsia
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    digestiveliver 
    CALM2 may serve as novel targets for the treatment of liver fibrosis
    ANIMAL & CELL MODELS