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FLASH GENE
Symbol LHCGR contributors: mct/npt - updated : 15-06-2017
HGNC name luteinizing hormone/choriogonadotropin receptor
HGNC id 6585
DNA
TYPE functioning gene
STRUCTURE 68.97 kb     11 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked Y status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 splicing 3093 - 699 - 2016 27061682
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinepancreas     Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
endocrinegonadal cell
Endocrineislet cell (alpha,beta...) Homo sapiens
Endocrinethyroid cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a large N terminal extracellular domain containing nine leucine-rich repeat motifs
  • a stretch of five amino acids Ala (A)-Phe (F)-Asn (N)-Gly (G)-Thr (T), highly conserved in glycoprotein hormone receptors
  • a C terminal half homolog of the rhodopsin-like receptors
  • conjugated GlycoP , PhosphoP
    HOMOLOGY
    interspecies ortholog to murine Lhcgr
    homolog to Drosophila Fsh
    homolog to C.elegans C50H2.1
    Homologene
    FAMILY
  • G-protein coupled receptor 1 family
  • FSH/LSH/TSH subfamily
  • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,organelle,lysosome
    basic FUNCTION
  • acting as luteinizing hormone/choriogonadotropin receptor (gonadotropin receptor)
  • regulating in males the devopment and function of Leyding cells
  • playing a role in male secondary sexual character development
  • is a G(s)-coupled GPCR that is essential for the maturation and function of the ovary and testis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text development of Leyding cells
    PATHWAY
    metabolism
    signaling hormonal
    a component
  • inactive mutant attenuates signaling of wild-type or constitutively active receptors via heterodimerization (Zhang 2009)
  • coexpression of the LHCGR and FSHR enables heterodimerizaton between the 2 gonadotropin receptors and results in an attenuation of signaling through each receptor
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MVK binds to the coding region of LHCGR mRNA, suppresses its translation, and the resulting ribonucleoprotein complex is targeted for degradation
  • ARF6 activated by the LHCGR through the cytohesin family of guanine nucleotide exchange factors mediates the receptor internalization and signaling
  • LHCGR signaling in regulating the AHR message involves protein kinase A pathway and is attributable to decreased transcription rate
  • lack of the physiological down regulation of LHCGR mRNA levels by ZFP36L2 in the ovaries is associated with anovulation and oocyte meiotic arrest
  • by inhibiting EIF5A hypusination, FSH reduces the expression of MVK that increases LHCGR mRNA expression by abrogating the inhibitory action of MVK
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) PHLCH , PPML
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation      
    secondary amenorrhea in females belonging to pedigrees of male patients with Leydig hypoplasia
    constitutional     --over  
    in granulosa cells (GC) from polycystic ovarian syndrome (PCOS) women
    constitutional germinal mutation      
    in empty follicle syndrome (EFS) in a family
    Susceptibility to endometrioid adenocarcinoma
    Variant & Polymorphism SNP
  • rs13405728 in gene LHCGR are associated with endometrioid adenocarcinoma
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS