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FLASH GENE
Symbol ZBTB42 contributors: mct - updated : 29-11-2016
HGNC name zinc finger and BTB domain containing 42
HGNC id 32550
DNA
TYPE functioning gene
STRUCTURE 4.12 kb     2 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 3651 47 422 - 2011 21193930
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivefemale systemovary  highly Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal highly Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • conserved N-terminal BTB domain, usually present as a single copy and implicated in protein–protein interactions
  • C-terminal four zinc finger domains
  • HOMOLOGY
    interspecies homolog to zebrafish zbtb42
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    text
  • distributed in the nucleoplasm, with particular enrichment in nuclei underlying the neuromuscular junctions
  • highly specific localization of ZBTB42 to the nucleoplasm of myofibrils, especially in nuclei at the NMJ
  • basic FUNCTION
  • may be involved in metabolic syndrome phenotypes
  • likely essential for normal muscle development
  • may play a role as a transcription factor that regulates the expression of important muscle developmental genes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) LCCS6
    Susceptibility to insulin resistance and development of the metabolic syndrome
    Variant & Polymorphism SNP
  • SNP that forms part of a small haplotype associated with increased risk of insulin resistance and the development of the metabolic syndrome
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • skeletal muscle of Zbtb42-deficient zebrafish lacked the clearly defined H-zone that is present in wild-type muscles