basic FUNCTION
| tissue factor pathway inhibitor |
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lipoprotein associated coagulation inhibitor (Xa, VIIa-TF inhibitor) |
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serine proteinase inhibitor |
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regulates factor X activation |
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primary physiologic inhibitor of tissue factor and is present within platelets |
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influences the angiogenic process via a non-haemostatic pathway, by downregulating the migratory mechanisms of endothelial cells |
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endogenous inhibitor regulating Tissue factor-induced blood coagulation |
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its presence in association with breast cancer cells localised in regional lymph nodes may indicate its role in lymphatic spread |
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with PROS1, act together in down-regulating coagulation |
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TFPI and PROS1 are major regulators of thrombin generation both in the absence and presence of activated protein C (APC) |
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primary physiological inhibitor of tissue factor (TF) induced coagulation |
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may, via its C terminus, modulate cell surface, heparin, and lipopolysaccharide interactions as well as participate in growth inhibition |
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role for TFPI in cutaneous defense against infections |