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FLASH GENE

Symbol

APOBEC3H

contributors: mct - updated : 18-12-2017

HGNC name	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H
HGNC id	24100

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
text	cluster of APOBEC3 (A3)2 genes encoding seven potential antiretroviral proteins : A3A, A3B, A3C, A3DE, A3F, A3G, and A3H
STRUCTURE	6.71 kb     5 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001166002 - - 1067 NP_001159474 - 182 - - NM_001166003 - - 1164 NP_001159475 - 200 - - NM_001166004 - - 639 NP_001159476 - 154 - - NM_181773 5 - 1070 NP_861438 21.5 183 - Vartanian (2008)

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine thyroid         Lymphoid/Immune thymus         Reproductive female system placenta       Skin/Tegument skin         Urinary kidney

cells

System Cell Pubmed Species Stage Rna symbol Skin/Tegument keratinocyte

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a Z2-type cytidine deaminase domain, which is evolutionarily distinct from the Z1-type domain of other APOBEC3
	two cytidine deaminase domains (CDD)( both active sites are required for antiviral function but serve separate functions)
	C-terminal deletion that impairs its mRNA expression
	Glu324 is a surface AA within the alpha4 helix adjacent to AAs corresponding to other known Vif susceptibility determinants in APOBEC3G and APOBEC3H

HOMOLOGY

Homologene

FAMILY

cytidine and deoxycytidylate deaminase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION

basic FUNCTION	functional, but poorly expressed, cytidine deaminase with no apparent antiviral activity
	having an anti-HIV potential
	APOBEC3 proteins function within the innate immune system by mutating DNA of viral genomes and retroelements to restrict infection and retrotransposition

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS