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FLASH GENE

Symbol

CEACAM16

contributors: mct - updated : 04-04-2023

HGNC name	carcinoembryonic antigen-related cell adhesion molecule 16
HGNC id	31948

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
STRUCTURE	11.56 kb     7 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001039213 7 - 1797 NP_001034302 - 484 - 2015 25589040

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Hearing/Equilibrium ear inner cochlea Corti specific Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Hearing / Equilibrium hair cell receptor Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

conjugated

GlycoP

HOMOLOGY

Homologene

FAMILY	immunoglobulin superfamily
	CEA family

CATEGORY

antigen

SUBCELLULAR LOCALIZATION	extracellular
	intracellular
	intracellular,cytoplasm,cytoskeleton,microtubule
text	present in the tectorial membrane (TM), an extracellular structure overlying the hearing organ of the inner ear, the organ of Corti

basic FUNCTION	can probably form higher order structures with other tectorial membrane proteins such as TECTA and TECTB and influences the physical properties of the tectorial membrane
	evolution of CEACAM16 might have been an important step for the specialization of the mammalian cochlea, allowing hearing over an extended frequency range
	TECTA, TECTB, and CEACAM16 are secreted glycoproteins that are present in the tectorial membrane (TM), an extracellular structure overlying the hearing organ of the inner ear, the organ of Corti

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	is an TECTA-interacting protein that concentrates at the point of attachment of the tectorial membrane (TM) to the stereocilia
	CEACAM16 interact with TECTA and TECTB, indicating that it may stabilize interactions between TECTA and TECTB

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

DFNA4B , DFNB113

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS