only ENH1 transcript was significant in the brain, and gradually reduced during postnatal heart development
2012
22497889
PDLIM5 Ia, or ENH1
overexpression of ENH1 in neonatal myocytes results in hypertrophy
the region including the three LIM domains of ENH1 (residues 415-591) appears to be sufficient for this PRKCB activation
13
-
5805
-
487
-
2012
22497889
PDLIM5 Ib
12
-
5713
36
271
-
2012
22497889
PDLIM5 Ic, ENH2
9
-
2131
26.3
234
predominant in cardiac and skeletal muscles in adult, and expression of ENH3 transcript was significant at birth and doubled in the late postnatal days
2012
22497889
PDLIM5 Id, ENH3
10
-
1971
24.5
214
present only in skeletal muscle and specific distribution of ENH members between skeletal and cardiac muscles, predominant in cardiac and skeletal muscles in adult, its level was below the detection limitation at the birth and in the early postnatal days, but became significant at the late postnatal days
2012
22497889
ENH4, lacking the C-terminal LIM domains present in ENH1 but containing the N-terminal PDZ domain
co-localize in the sarcomeric Z-band and interact with alpha-actinin like the other members of the ENH family
17
-
6219
-
625
-
2012
22497889
15
-
3834
-
483
-
2012
22497889
12
-
5980
-
474
-
2012
22497889
3
-
1223
-
136
-
2012
22497889
EXPRESSION
Type
ubiquitous
expressed in
(based on citations)
organ(s)
System
Organ level 1
Organ level 2
Organ level 3
Organ level 4
Level
Pubmed
Species
Stage
Rna symbol
Cardiovascular
heart
highly
Respiratory
respiratory tract
larynx
highly
tissue
System
Tissue
Tissue level 1
Tissue level 2
Level
Pubmed
Species
Stage
Rna symbol
Muscular
striatum
skeletal
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
a 100-amino acid PDZ domain in the N terminus
3 LIM domains in the C terminus, which bind to the helix-loop-helix domain of ID proteins
involved in cytoskeleton organization, cell lineage specification, organ development, and oncogenesis
actin-associated protein acting as a cytoplasmic retention factor for ID2
contributing to differentiation of the nervous system through cytoplasmic sequestration of ID2 and acting as a restraining factor of the oncogenic activity of ID proteins in neural tumors
plays an important role in linking protein kinase C with calcium channel
acts as a scaffold to tether various functional proteins at subcellular sites via PDZ and three LIM domains
LDB3 and PDLIM5 redundantly play an essential role in sustaining Z-line structure from the earliest stages of cardiac function, and are redundantly required to maintain normal embryonic heart function and embryonic viability
CELLULAR PROCESS
PHYSIOLOGICAL PROCESS
development
PATHWAY
metabolism
signaling
a component
INTERACTION
DNA
RNA
small molecule
protein
interacting specifically with protein kinase C-epsilon (PRKCE) and the C terminus of the N-type calcium channel alpha-1B subunit (CACNA1B) to form a macromolecular complex
interacting with ID proteins
PDLIM5 could selectively recruit PRKCE to its specific substrate in neurons
cell & other
REGULATION
Phosphorylated by
PRKAA1 and its phosphorylation on Ser177 by PRKAA1 mediates inhibition of cell migration by suppressing the RAC1-Arp2/3 signalling pathway
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
Type
Gene Modification
Chromosome rearrangement
Protein expression
Protein Function
constitutional
--over
during neural differentiation
Susceptibility
to bipolar disorder, and schizophrenia
Variant & Polymorphism
SNP
nonsynonymous rs7690296 polymorphism could play an important role in the pathophysiology of both bipolar disorder and schizophrenia
