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FLASH GENE

Symbol

NEXMIF

contributors: mct - updated : 09-10-2017

HGNC name	neurite extension and migration factor
HGNC id	29433

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	192.60 kb     4 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

Map	cen - XIST - DXS8066 - SLC16A2 - KIAA2022 - ABCB7 - DXS441 - DXS347 - qter
Authors	Cantagrel (04)

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001008537 4 - 11727 NP_001008537 167 1516 - 2016 27822498

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain forebrain cerebral cortex   highly Homo sapiens Fetal   brain hindbrain cerebellum     Reproductive female system ovary       Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Nervous peripherous     highly Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Nervous neuron Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text

brain

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

HOMOLOGY

Homologene

FAMILY

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus
text	highly expressed in postmitotic neuronsv

basic FUNCTION	may play a role in postmitotic, maturing neurons
	may participate in neural circuit formation during developmental stages via nuclear and cytoplasmic KIAA2022
	major role in neuron development and brain function, and is essential for proper brain development
	regulates cell-cell and cell-matrix adhesion and cellular migration by regulating the expression of adhesion molecules
	plays important roles in the control of neuronal migration and morphogenesis

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

AUTSX7 , MRX98 , DUPXQ13

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional         disrupted in a pericentric inversion in two mentally retarded brothers

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS