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FLASH GENE

Symbol

LRRK1

contributors: - updated : 21-05-2011

HGNC name	leucine-rich repeat kinase 1
HGNC id	18608

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	150.86 kb     35 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_024652 35 - 7647 - 2015 - 2007 17225181

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine pancreas         Lymphoid/Immune thymus         Homo sapiens Nervous brain forebrain cerebral cortex     Homo sapiens   brain limbic system hippocampus     Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	two SH2 domains
	unusual structure with a central GTPase domain, which regulates its kinase activity
	a MAPKKK-like kinase domain

HOMOLOGY

interspecies

homolog to murine Lrrk1

intraspecies

paralog to LRRK2

Homologene

FAMILY	TYR family of protein kinases
	SYK/ZAP-70 subfamily
	ROCO family of complex proteins

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria
	intracellular,cytoplasm,organelle,endosome
text	LRRK1 and epidermal growth factor (EGF) are internalized and co-localized in early endosomes

basic FUNCTION	GTP-regulated protein kinase harboring both the kinase effector domain and the GTP-binding regulatory domain
	possible redundancy in the cerebral function between LRRK1 and LRRK2
	proximal signaling component of the BCR-ABL1 network
	regulates EGFR transport from early to late endosomes and regulates the motility of EGF-containing early endosomes in a manner dependent on its kinase activity
	MAPKKK-like protein that regulates the endosomal trafficking of EGFR

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component	forms a complex with activated EGFR through an interaction with GRB2
	part of the the GRB2/GAB2/SHC1 inner core complex, a signal integrator complex functionally involved in the balance of cellular stress responses

INTERACTION

DNA

RNA

small molecule	nucleotide,
	binding of GTP to LRRK1 is specific, requires the GTPase-like Roc domain, and leads to a stimulation of LRRK1 kinase activity

protein	interaction with GRB2
	protein interacting with GRB2 and SHC1

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS